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Deregulation of the circadian clock constitutes a significant factor in tumorigenesis:a clockwork cancer. Part II. In vivo studies

机译:昼夜节律的失调是肿瘤发生的重要因素:发条癌症。第二部分体内研究

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摘要

The uneventful progression through the cell cycle is closely associated with the rhythm set by the circadian clock machinery, with the S-phase of the cell cycle typically occurring at night. Presence of unrepaired DNA damage may reset the phase of the circadian clock, providing opportunities for damage assessment, repair and/or the induction of pro-apoptotic pathways. The core proteins of the circadian clock regulate directly or indirectly a significant number of genes coding for proteins involved in checkpoint transition, cell proliferation and programmed cell death. Disruption of the circadian rhythm may increase the risk for some multifactorial diseases and conditions, including glucose intolerance, cardiovascular disease and various common cancers. In patients with cancer, chronic circadian misalignment may stimulate the growth of tumours and may modify the outcomes of anticancer therapy. Knowledge about the role of physiological rhythms in human disease may contribute to the field of individualized medicine, specifically, in risk assessment and prognostication of the outcomes in patients with multifactorial disease.
机译:整个细胞周期的平稳进行与生物钟机制设定的节奏密切相关,细胞周期的S期通常在夜间发生。未修复的DNA损伤的存在可能会重置生物钟的相位,从而为损伤评估,修复和/或诱导促凋亡途径提供机会。昼夜节律时钟的核心蛋白直接或间接调节大量基因,这些基因编码涉及检查点转换,细胞增殖和程序性细胞死亡的蛋白质。昼夜节律的破坏可能增加某些多因素疾病和状况的风险,包括葡萄糖耐量异常,心血管疾病和各种常见癌症。在患有癌症的患者中,慢性昼夜节律失调可能会刺激肿瘤的生长,并可能改变抗癌治疗的结果。有关生理节律在人类疾病中的作用的知识可能有助于个体化医学领域,特别是在多因素疾病患者的风险评估和预后评估方面。

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  • 作者

    Uth, Kristin; Sleigh, Roger;

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  • 年度 2014
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  • 原文格式 PDF
  • 正文语种 eng
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